Acid Zoledronic: aafiaga pharmacological ma analogues

E iloa e matele bisphosphonates e taofiofia le atinae o ivi metastasis ma taofia leiloa ivi. O se tasi o fualaau faasaina e sili ona lelei le auai i lenei vaega - acid zoledronic. Foi, o se faamaoniga lea o lenei fualaau faasaina ei ai angioneogenesis inhibition, osofaiga patu, adhesion o sela patu i le aano o ivi, faatosina apoptosis, ma o loo i ai synergy ma togafitiga.

Tuufaatasia 1 ipu

monohydrate acid Zoledronic - 4,26 Excipients mg - Sodium citrate, D-mannitol.

pharmacology

O se inhibitor o resorption ivi. acid Zoledronic ea i se vasega fou o le vasega maualuga o bisphosphonates. O loo i ai se aafiaga filifili i ivi. Faaitiitia ai le gaoioiga o osteoclasts, e aunoa ma mafua ai se aafiaga le lelei i le faavaeina ma isi uiga o le pepa solo ivi. O le aafiaga o bisphosphonates i ivi o loo faavae i luga o se tutusa maualuga e ivi mineralized, ae o le faiga tonu o molecules e maua mai inhibiting le gaoioiga o osteoclasts, i lenei aso e le i suesueina pea. Foi ei ai se tuusao meatotino aneti-patu, faamautinoaina o le lelei i metastasis ivi.

I to faamili iloa acid zoledronic, faatosina apoptosis ma inhibiting proliferation o sela i ai o se aafiaga antitumor tuusao i myeloma, faapea foi i le sela o le kanesa o le susu, ae o le faaitiitia o tulaga lamatia o metastasis. Foi, acid zoledronic ai se meatotino a le faaitiitia o le faasalaga kalisiu i hypercalcemia serum, lea e mafua mai i se tuma.

faailoga

• manuʻa Osteolytic i foci tele myeloma.
• Osteoblastic, metastasis osteolytic fefiloi ivi o tumors tele.
• Hypercalcemia, lea e mafua mai i malignancy.

Contraindications

• Maitaga ma le susu-fafagaina.
• le atoatoa Fatugao.
• Fanau ma talavou (talosaga saogalemu e le i faavaeina).
• Hypersensitivity e bisphosphonates ma acid zoledronic.
• Puipuiga: dysfunction Fatugao, sela bronchial, toilalo hepatic.

itu aafiaga

Anemia, thrombocytopenia, tiga le ulu, dizziness, conjunctivitis, faafaufau, anorexia, faasuati, manavatatā, tiga ivi, arthralgia, hypophosphatemia, hypocalcemia, fiva, syndrome fulū, vaivai, maua mamafa. I le togafitiga o gasegase ma acid zoledronic o nisi taimi e matauina le atinae o osteonecrosis o le auvae (e masani lava ina ua uma le fesoasoaniga taotoga o nifo).

Dosing

sisina totonu o le uaua, ma totonu o le 15 minute, ae e lē itiiti ifo. Metastases o myeloma tele fautuaina inumaga o 4 mg faatasi i le masina. A hypercalcemia, lea e mafua mai i se patu matuia, a inumaga o 4 mg le taimi e tasi i aso taitasi.

lapataiga

Le taimi lava e le fualaau faasaina faafoeina, e tatau ona pulea le faasalaga o magnesium, phosphorus, creatinine ma kalisiu i serum toto. Afai e mafai, e fautuaina ina ia aloese mai se taotoga o nifo.

acid Zoledronic. analogs

Fualaau faasaina "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

acid Zoledronic. tau

E masani lava, o nofoaga o aafia i le tufatufaina atu o vailaau i totonu o le tulafono, e faailoa ai le tau mo a latou oloa. Ae, oddly lava, o le tau o zoledronic acid e masani ona faailoa mai pe tusa. Ae e oo tusa ma lona taua e uiga i le 14 afe rubles i le fagu. Faatauina atu i pharmacies e talavai na.

ua faamoemoe le faamatalaga i luga e faamasani tagata faigaluega o le soifua maloloina. O lenei mataupu faavae e faatatau lea i acid zoledronic e le suitulaga fautuaga agavaa o se fomai, ma e le mafai ona tuuina atu se faamaoniga o se aafiaga lelei mai le faaaogaina o le fualaau faasaina.